Cargando…

The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro

BACKGROUND: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current treatment dampens inflammation while new bone formation can progress. Therefore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stougaard, Julie, Lomholt, Søren, Ommen, Pernille, Kelsen, Jens, Kragstrup, Tue W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390625/ https://www.ncbi.nlm.nih.gov/pubmed/30886983 http://dx.doi.org/10.1186/s41927-018-0040-9

Ejemplares similares

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis
por: Køster, Ditte, et al.
Publicado: (2021)

Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation
por: Vu, Tuong N., et al.
Publicado: (2019)

Antifibrotic Effects of Caffeine, Curcumin and Pirfenidone in Primary Human Keratocytes
por: Talpan, Delia, et al.
Publicado: (2023)

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis
por: Komiya, Chikara, et al.
Publicado: (2017)

Pharmacological basis of the antifibrotic effects of pirfenidone: Mechanistic insights from cardiac in-vitro and in-vivo models
por: Sartiani, Laura, et al.
Publicado: (2022)

The synovial proteome: analysis of fibroblast-like synoviocytes
por: Dasuri, Kumar, et al.
Publicado: (2004)

Simvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes
por: Litinsky, Ira, et al.
Publicado: (2009)

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes
por: Qiao, Li, et al.
Publicado: (2020)

The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis
por: Kragstrup, Tue W., et al.
Publicado: (2018)

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis
por: Korfei, Martina, et al.
Publicado: (2018)

Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis
por: Ebrahimpour, Afshin, et al.
Publicado: (2022)

Expression of interleukin-18 receptor in fibroblast-like synoviocytes
por: Möller, Burkhard, et al.
Publicado: (2002)

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis
por: Bustamante, Marta F., et al.
Publicado: (2017)

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes
por: Lin, Jin, et al.
Publicado: (2019)

A microfluidic chip-based co-culture of fibroblast-like synoviocytes with osteoblasts and osteoclasts to test bone erosion and drug evaluation
por: Ma, Hui-Peng, et al.
Publicado: (2018)

Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
por: Birkelund, Svend, et al.
Publicado: (2020)

PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro
por: Yao, Yao, et al.
Publicado: (2018)

Responses to Cytokine Inhibitors Associated with Cellular Composition in Models of Immune‐Mediated Inflammatory Arthritis
por: Nielsen, Morten A., et al.
Publicado: (2019)

Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes
por: Bauer, Stefan, et al.
Publicado: (2006)

Effects of hypoxia on protein and gene expression in fibroblast-like synoviocytes
por: El-Gabalawy, H, et al.
Publicado: (2004)

Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
por: Kaneko, Kayoko, et al.
Publicado: (2011)

Fibroblast-Like Synoviocytes Induce Calcium Mineral Formation and Deposition
por: Sun, Yubo, et al.
Publicado: (2014)

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
por: Ai, Rizi, et al.
Publicado: (2018)

Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes
por: Yoshitomi, Hiroyuki
Publicado: (2019)

IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis
por: Kragstrup, Tue W., et al.
Publicado: (2019)

Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
por: Wu, Jing, et al.
Publicado: (2019)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

Effects of the pro-inflammatory milieu on the dedifferentiation of cultured fibroblast-like synoviocytes
por: CHOI, HONG SEO, et al.
Publicado: (2012)

Metabolomic Elucidation of the Effects of Curcumin on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
por: Ahn, Joong Kyong, et al.
Publicado: (2015)

The emerging role of fibroblast‐like synoviocytes‐mediated synovitis in osteoarthritis: An update
por: Han, Dafei, et al.
Publicado: (2020)

Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
por: He, Shou-Di, et al.
Publicado: (2020)

Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes
por: Malaise, Olivier, et al.
Publicado: (2021)

CCL22 induces pro-inflammatory changes in fibroblast-like synoviocytes
por: Ren, Guomin, et al.
Publicado: (2020)

Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes
por: Torres, Alyssa, et al.
Publicado: (2022)

Inflammation-Driven Secretion Potential Is Upregulated in Osteoarthritic Fibroblast-Like Synoviocytes
por: Chwastek, Jakub, et al.
Publicado: (2022)

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes
por: Timm, Thomas, et al.
Publicado: (2023)

PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53
por: You, Xin, et al.
Publicado: (2006)

Cadherin-11 Provides Specific Cellular Adhesion between Fibroblast-like Synoviocytes
por: Valencia, Xavier, et al.
Publicado: (2004)

TRAIL-induced rheumatoid arthritis fibroblast-like synoviocyte proliferation is inhibited by OPG
por: Morel, J, et al.
Publicado: (2004)

Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
por: Hardy, Rowan S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_m82o85ebai6kuf697n18kd9kng