microRNA-142–mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

Tregs play a fundamental role in immune tolerance via control of self-reactive effector T cells (Teffs). This function is dependent on maintenance of a high intracellular cAMP concentration. A number of microRNAs are implicated in the maintenance of Tregs. In this study, we demonstrate that peripher...

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Detalles Bibliográficos
Autores principales: Anandagoda, Nelomi, Willis, Joanna C.D., Hertweck, Arnulf, Roberts, Luke B., Jackson, Ian, Gökmen, M. Refik, Jenner, Richard G., Howard, Jane K., Lord, Graham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391082/
https://www.ncbi.nlm.nih.gov/pubmed/30741720
http://dx.doi.org/10.1172/JCI124725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391082/
https://www.ncbi.nlm.nih.gov/pubmed/30741720
http://dx.doi.org/10.1172/JCI124725

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