Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis

BACKGROUND. Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently observed, the mechanisms and impact of emerge...

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Detalles Bibliográficos
Autores principales: Stone, Neil R.H., Rhodes, Johanna, Fisher, Matthew C., Mfinanga, Sayoki, Kivuyo, Sokoine, Rugemalila, Joan, Segal, Ella Shtifman, Needleman, Leor, Molloy, Síle F., Kwon-Chung, June, Harrison, Thomas S., Hope, William, Berman, Judith, Bicanic, Tihana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391087/
https://www.ncbi.nlm.nih.gov/pubmed/30688656
http://dx.doi.org/10.1172/JCI124516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391087/
https://www.ncbi.nlm.nih.gov/pubmed/30688656
http://dx.doi.org/10.1172/JCI124516

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