Comparison of Effects of Anti-thrombin Aptamers HD1 and HD22 on Aggregation of Human Platelets, Thrombin Generation, Fibrin Formation, and Thrombus Formation Under Flow Conditions

HD1 and HD22 are two of the most-studied aptamers binding to thrombin exosite I and exosite, respectively. To complete of their pharmacological profiles, the effects of HD1 and HD22 on thrombin-, ristocetin-, and collagen-induced human platelet aggregation, on thrombin generation and fibrin formatio...

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Detalles Bibliográficos
Autores principales: Derszniak, Katarzyna, Przyborowski, Kamil, Matyjaszczyk, Karolina, Moorlag, Martijn, de Laat, Bas, Nowakowska, Maria, Chlopicki, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391317/
https://www.ncbi.nlm.nih.gov/pubmed/30842734
http://dx.doi.org/10.3389/fphar.2019.00068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391317/
https://www.ncbi.nlm.nih.gov/pubmed/30842734
http://dx.doi.org/10.3389/fphar.2019.00068

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