Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury

ATP depletion and succinate accumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia at low temperatures without suffering from oxidative damage upon reoxygenation, but the mechanisms are unclear. To determine...

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Detalles Bibliográficos
Autores principales: Bundgaard, Amanda, James, Andrew M., Gruszczyk, Anja V., Martin, Jack, Murphy, Michael P., Fago, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391391/
https://www.ncbi.nlm.nih.gov/pubmed/30808950
http://dx.doi.org/10.1038/s41598-019-39836-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391391/
https://www.ncbi.nlm.nih.gov/pubmed/30808950
http://dx.doi.org/10.1038/s41598-019-39836-5

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