Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-β1 as strongly upregulated molecules involved in adjuvant activity

Cholera Toxin (CT) as well as its related non-toxic mmCT and dmLT mutant proteins have been shown to be potent adjuvants for mucosally administered vaccines. Their adjuvant activity involves activation of cAMP/protein kinase A (PKA) signaling and inflammasome/IL-1β pathways in antigen presenting cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Terrinoni, Manuela, Holmgren, Jan, Lebens, Michael, Larena, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391456/
https://www.ncbi.nlm.nih.gov/pubmed/30808871
http://dx.doi.org/10.1038/s41598-019-38726-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391456/
https://www.ncbi.nlm.nih.gov/pubmed/30808871
http://dx.doi.org/10.1038/s41598-019-38726-0

Ejemplares similares