Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma

Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC). High levels of endogenous arginase 2 (ARG2) have been previously reported in human l...

Descripción completa

Detalles Bibliográficos
Autores principales: Lam, Sze-Kwan, Yan, Sheng, Xu, Shi, U, Kin-Pong, Cheng, Paul Ning-Man, Ho, James Chung-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391460/
https://www.ncbi.nlm.nih.gov/pubmed/30808864
http://dx.doi.org/10.1038/s41389-019-0128-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391460/
https://www.ncbi.nlm.nih.gov/pubmed/30808864
http://dx.doi.org/10.1038/s41389-019-0128-0

Ejemplares similares