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Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma
Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC). High levels of endogenous arginase 2 (ARG2) have been previously reported in human l...
Autores principales: | Lam, Sze-Kwan, Yan, Sheng, Xu, Shi, U, Kin-Pong, Cheng, Paul Ning-Man, Ho, James Chung-Man |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391460/ https://www.ncbi.nlm.nih.gov/pubmed/30808864 http://dx.doi.org/10.1038/s41389-019-0128-0 |
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