Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight

Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer’s disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hypoperfusion may exacerbate AD pathology. We applied b...

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Detalles Bibliográficos
Autores principales: Bannai, Taro, Mano, Tatsuo, Chen, Xigui, Ohtomo, Gaku, Ohtomo, Ryo, Tsuchida, Takeyuki, Koshi-Mano, Kagari, Hashimoto, Tadafumi, Okazawa, Hitoshi, Iwatsubo, Takeshi, Tsuji, Shoji, Toda, Tatsushi, Iwata, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391466/
https://www.ncbi.nlm.nih.gov/pubmed/30808940
http://dx.doi.org/10.1038/s41598-019-39494-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391466/
https://www.ncbi.nlm.nih.gov/pubmed/30808940
http://dx.doi.org/10.1038/s41598-019-39494-7

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