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Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer’s disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hypoperfusion may exacerbate AD pathology. We applied b...
Autores principales: | Bannai, Taro, Mano, Tatsuo, Chen, Xigui, Ohtomo, Gaku, Ohtomo, Ryo, Tsuchida, Takeyuki, Koshi-Mano, Kagari, Hashimoto, Tadafumi, Okazawa, Hitoshi, Iwatsubo, Takeshi, Tsuji, Shoji, Toda, Tatsushi, Iwata, Atsushi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391466/ https://www.ncbi.nlm.nih.gov/pubmed/30808940 http://dx.doi.org/10.1038/s41598-019-39494-7 |
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