Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning

Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated “base editing” being limited to certain nucleotide changes, and only achievable within a small window around CRISPR-Cas target sites. The more versatile a...

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Detalles Bibliográficos
Autores principales: O’Brien, Aidan R., Wilson, Laurence O. W., Burgio, Gaetan, Bauer, Denis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391469/
https://www.ncbi.nlm.nih.gov/pubmed/30808944
http://dx.doi.org/10.1038/s41598-019-39142-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391469/
https://www.ncbi.nlm.nih.gov/pubmed/30808944
http://dx.doi.org/10.1038/s41598-019-39142-0

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