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Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning
Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated “base editing” being limited to certain nucleotide changes, and only achievable within a small window around CRISPR-Cas target sites. The more versatile a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391469/ https://www.ncbi.nlm.nih.gov/pubmed/30808944 http://dx.doi.org/10.1038/s41598-019-39142-0 |