A network-centric approach to drugging TNF-induced NF-κB signaling

Target-centric drug development strategies prioritize single-target potency in vitro and do not account for connectivity and multi-target effects within a signal transduction network. Here, we present a systems biology approach that combines transcriptomic and structural analyses with live-cell imag...

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Detalles Bibliográficos
Autores principales: Pabon, Nicolas A., Zhang, Qiuhong, Cruz, J. Agustin, Schipper, David L., Camacho, Carlos J., Lee, Robin E. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391473/
https://www.ncbi.nlm.nih.gov/pubmed/30808860
http://dx.doi.org/10.1038/s41467-019-08802-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391473/
https://www.ncbi.nlm.nih.gov/pubmed/30808860
http://dx.doi.org/10.1038/s41467-019-08802-0

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