Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Aberrant activation of the Wnt/β-catenin signaling pathway promotes the progression of osteoarthritis (OA). We previously reported that R-spondin 2 (Rspo2), an activator of the Wnt/β-catenin signaling, facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhanc...

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Detalles Bibliográficos
Autores principales: Okura, Toshiaki, Ohkawara, Bisei, Takegami, Yasuhiko, Ito, Mikako, Masuda, Akio, Seki, Taisuke, Ishiguro, Naoki, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391487/
https://www.ncbi.nlm.nih.gov/pubmed/30808932
http://dx.doi.org/10.1038/s41598-019-39393-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391487/
https://www.ncbi.nlm.nih.gov/pubmed/30808932
http://dx.doi.org/10.1038/s41598-019-39393-x

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