Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors

AIM: TAp73 is a tumor suppressor, which compensates for p53 loss and induces apoptosis in tumors in response to genotoxic stress or small-molecule treatments. Pancreatic ductal adenocarcinoma has a late onset of the disease, responds poorly to the existing therapies and has a very low survival rates...

Descripción completa

Detalles Bibliográficos
Autores principales: Acedo, Pilar, Fernandes, Aristi, Zawacka-Pankau, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391631/
https://www.ncbi.nlm.nih.gov/pubmed/30820346
http://dx.doi.org/10.4155/fsoa-2018-0082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391631/
https://www.ncbi.nlm.nih.gov/pubmed/30820346
http://dx.doi.org/10.4155/fsoa-2018-0082

Ejemplares similares