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Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors

AIM: TAp73 is a tumor suppressor, which compensates for p53 loss and induces apoptosis in tumors in response to genotoxic stress or small-molecule treatments. Pancreatic ductal adenocarcinoma has a late onset of the disease, responds poorly to the existing therapies and has a very low survival rates...

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Detalles Bibliográficos
Autores principales:	Acedo, Pilar, Fernandes, Aristi, Zawacka-Pankau, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Science Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391631/ https://www.ncbi.nlm.nih.gov/pubmed/30820346 http://dx.doi.org/10.4155/fsoa-2018-0082

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