Chemo‐Enzymatic Synthesis of Pyrazines and Pyrroles

Herein we report the biocatalytic synthesis of substituted pyrazines and pyrroles using a transaminase (ATA) to mediate the key amination step of the ketone precursors. Treatment of α‐diketones with ATA‐113 in the presence of a suitable amine donor yielded the corresponding α‐amino ketones which und...

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Detalles Bibliográficos
Autores principales: Xu, Jin, Green, Anthony P., Turner, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391939/
https://www.ncbi.nlm.nih.gov/pubmed/30335228
http://dx.doi.org/10.1002/anie.201810555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391939/
https://www.ncbi.nlm.nih.gov/pubmed/30335228
http://dx.doi.org/10.1002/anie.201810555

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