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Chemo‐Enzymatic Synthesis of Pyrazines and Pyrroles

Herein we report the biocatalytic synthesis of substituted pyrazines and pyrroles using a transaminase (ATA) to mediate the key amination step of the ketone precursors. Treatment of α‐diketones with ATA‐113 in the presence of a suitable amine donor yielded the corresponding α‐amino ketones which und...

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Detalles Bibliográficos
Autores principales:	Xu, Jin, Green, Anthony P., Turner, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391939/ https://www.ncbi.nlm.nih.gov/pubmed/30335228 http://dx.doi.org/10.1002/anie.201810555

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