Enantiospecific Synthesis of ortho‐Substituted 1,1‐Diarylalkanes by a 1,2‐Metalate Rearrangement/anti‐S(N)2′ Elimination/Rearomatizing Allylic Suzuki–Miyaura Reaction Sequence

The one‐pot sequential coupling of benzylamines, boronic esters, and aryl iodides has been investigated. In the presence of an N‐activator, the boronate complex formed from an ortho‐lithiated benzylamine and a boronic ester undergoes stereospecific 1,2‐metalate rearrangement/anti‐S(N)2′ elimination...

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Detalles Bibliográficos
Autores principales: Rubial, Belén, Collins, Beatrice S. L., Bigler, Raphael, Aichhorn, Stefan, Noble, Adam, Aggarwal, Varinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391954/
https://www.ncbi.nlm.nih.gov/pubmed/30520228
http://dx.doi.org/10.1002/anie.201811343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391954/
https://www.ncbi.nlm.nih.gov/pubmed/30520228
http://dx.doi.org/10.1002/anie.201811343

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