Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histon...

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Detalles Bibliográficos
Autores principales: Anderson, Cathy J., Baird, Matthew R., Hsu, Allen, Barbour, Emily H., Koyama, Yuka, Borgnia, Mario J., McGinty, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392056/
https://www.ncbi.nlm.nih.gov/pubmed/30759380
http://dx.doi.org/10.1016/j.celrep.2019.01.058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392056/
https://www.ncbi.nlm.nih.gov/pubmed/30759380
http://dx.doi.org/10.1016/j.celrep.2019.01.058

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