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Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase
Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histon...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392056/ https://www.ncbi.nlm.nih.gov/pubmed/30759380 http://dx.doi.org/10.1016/j.celrep.2019.01.058 |