A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF(high)/AXL(low) melanoma

The BRAF kinase and the MAPK pathway are targets of current melanoma therapies. However, MAPK pathway inhibition results in dynamic changes of downstream targets that can counteract inhibitor‐action not only in during treatment, but also in acquired resistant tumours. One such dynamic change involve...

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Detalles Bibliográficos
Autores principales: Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392120/
https://www.ncbi.nlm.nih.gov/pubmed/30277012
http://dx.doi.org/10.1111/pcmr.12741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392120/
https://www.ncbi.nlm.nih.gov/pubmed/30277012
http://dx.doi.org/10.1111/pcmr.12741

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