Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

The DNA repair protein O(6)-methylguanine DNA methyltransferase (MGMT) strongly influences the effectiveness of cancer treatment with chemotherapeutic alkylating agents, and MGMT status in cancer cells could potentially contribute to tailored therapies for individual patients. However, the promoter...

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Detalles Bibliográficos
Autores principales: Nagel, Zachary D., Beharry, Andrew A., Mazzucato, Patrizia, Kitange, Gaspar J., Sarkaria, Jann N., Kool, Eric T., Samson, Leona D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392231/
https://www.ncbi.nlm.nih.gov/pubmed/30811507
http://dx.doi.org/10.1371/journal.pone.0208341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392231/
https://www.ncbi.nlm.nih.gov/pubmed/30811507
http://dx.doi.org/10.1371/journal.pone.0208341

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