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Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells
The DNA repair protein O(6)-methylguanine DNA methyltransferase (MGMT) strongly influences the effectiveness of cancer treatment with chemotherapeutic alkylating agents, and MGMT status in cancer cells could potentially contribute to tailored therapies for individual patients. However, the promoter...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392231/ https://www.ncbi.nlm.nih.gov/pubmed/30811507 http://dx.doi.org/10.1371/journal.pone.0208341 |