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Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis

Alzheimer disease (AD) is a progressive neurodegenerative disease, the etiology of which remains largely unknown. Accumulating evidence indicates that elevated manganese (Mn) in brain exerts toxic effects on neurons and contributes to AD development. Thus, we aimed to explore the gene and pathway va...

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Detalles Bibliográficos
Autores principales: Ling, JunJun, Yang, Shengyou, Huang, Yi, Wei, Dongfeng, Cheng, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392515/
https://www.ncbi.nlm.nih.gov/pubmed/29851783
http://dx.doi.org/10.1097/MD.0000000000010775