Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) work in conjunction with adenylate/guanylate cyclases to regulate the key second messengers of G protein–coupled receptor signaling. Previous attempts to determine the full-length structure of PDE family members at high-resolution have been hindered by str...

Descripción completa

Detalles Bibliográficos
Autores principales: Gulati, Sahil, Palczewski, Krzysztof, Engel, Andreas, Stahlberg, Henning, Kovacik, Lubomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392808/
https://www.ncbi.nlm.nih.gov/pubmed/30820458
http://dx.doi.org/10.1126/sciadv.aav4322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392808/
https://www.ncbi.nlm.nih.gov/pubmed/30820458
http://dx.doi.org/10.1126/sciadv.aav4322

Ejemplares similares