Cargando…

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

The accumulation of aggregated amyloid-β (Aβ) in the brain is the first critical step in the pathogenesis of Alzheimer’s disease (AD), which also includes synaptic impairment, neuroinflammation, neuronal loss, and eventual cognitive defects. Emerging evidence suggests that impairment of Aβ phagocyto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Rui-Yuan, Ma, Jun, Kong, Xiang-Xi, Wang, Xiao-Feng, Li, Shuo-Shuo, Qi, Xiao-Long, Yan, Yu-Han, Cheng, Jinbo, Liu, Qingsong, Jin, Wanzhu, Tan, Chang-Heng, Yuan, Zengqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393001/ https://www.ncbi.nlm.nih.gov/pubmed/30820451 http://dx.doi.org/10.1126/sciadv.aau6328

Ejemplares similares

Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology
por: Cheng, Jinbo, et al.
Publicado: (2021)

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance
por: Bai, Yao, et al.
Publicado: (2019)

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
por: El Hajj, Hassan, et al.
Publicado: (2019)

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2020)

HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway
por: Liao, Yajin, et al.
Publicado: (2020)

Correction to: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2022)

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
por: Sun, Xiao-ying, et al.
Publicado: (2021)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology
por: Thal, Dietmar R.
Publicado: (2015)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
por: Li, Shuoshuo, et al.
Publicado: (2021)

Editorial on, “Amyloid-beta clearance in Alzheimer's disease”
por: Marr, Robert A.
Publicado: (2014)

Microglial immunophenotype in dementia with Alzheimer’s pathology
por: Minett, Thais, et al.
Publicado: (2016)

Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury
por: Li, Xiaoheng, et al.
Publicado: (2020)

DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
por: Choi, Chiyeol, et al.
Publicado: (2022)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
por: Guedes, Joana R., et al.
Publicado: (2018)

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression
por: Fernández-Mendívil, Cristina, et al.
Publicado: (2020)

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
por: Braun, David J., et al.
Publicado: (2020)

Rutin pretreatment promotes microglial M1 to M2 phenotype polarization
por: Lang, Guang-Ping, et al.
Publicado: (2021)

Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer's Disease
por: Zhang, Heng, et al.
Publicado: (2020)

Evidence for impaired amyloid β clearance in Alzheimer's disease
por: Wildsmith, Kristin R, et al.
Publicado: (2013)

Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model
por: Tai, Yi-Heng, et al.
Publicado: (2018)

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
por: Lin, Geng, et al.
Publicado: (2020)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor
por: Maeda, Jun, et al.
Publicado: (2021)

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways
por: Tsay, Huey-Jen, et al.
Publicado: (2021)

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice
por: Peng, Zhixin, et al.
Publicado: (2021)

Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein
por: Wang, Chung-Jen, et al.
Publicado: (2013)

Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease
por: Chen, Yijing, et al.
Publicado: (2020)

Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer’s disease mouse model
por: Kim, Namkwon, et al.
Publicado: (2023)

Therapeutic Potential of Direct Clearance of the Amyloid-β in Alzheimer’s Disease
por: Kim, Dong Eun, et al.
Publicado: (2020)

Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
por: Li, Yi, et al.
Publicado: (2022)

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease
por: Xiang, Yang, et al.
Publicado: (2015)

An “Amyloid‐β Cleaner” for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction
por: Liu, Ruiyuan, et al.
Publicado: (2019)

A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer’s Disease
por: Bermejo-Bescós, Paloma, et al.
Publicado: (2023)

Rutin Ameliorates Cyclophosphamide-induced Reproductive Toxicity in Male Rats
por: Abarikwu, S. O., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jik88tdc2br0viuvkn81833ki0