Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries

Adenosine to inosine editing is common in the human transcriptome and changes of this essential activity is associated with disease. Children with ADAR1 mutations develop fatal Aicardi-Goutières syndrome characterized by aberrant interferon expression. In contrast, ADAR1 overexpression is associated...

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Detalles Bibliográficos
Autores principales: Fritzell, Kajsa, Xu, Li-Di, Otrocka, Magdalena, Andréasson, Claes, Öhman, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393238/
https://www.ncbi.nlm.nih.gov/pubmed/30590609
http://dx.doi.org/10.1093/nar/gky1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393238/
https://www.ncbi.nlm.nih.gov/pubmed/30590609
http://dx.doi.org/10.1093/nar/gky1228

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