Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo

Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes place in the context of 5′ flap structures generated via strand-displacement synthesis by DNA polymerase delta. At least three DNA nucleases: Rad27 (Fen...

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Detalles Bibliográficos
Autores principales: Kahli, Malik, Osmundson, Joseph S, Yeung, Rani, Smith, Duncan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393292/
https://www.ncbi.nlm.nih.gov/pubmed/30541106
http://dx.doi.org/10.1093/nar/gky1242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393292/
https://www.ncbi.nlm.nih.gov/pubmed/30541106
http://dx.doi.org/10.1093/nar/gky1242

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