Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex

Intrinsically disordered regions (IDRs) are present in at least 30% of the eukaryotic proteome and are enriched in chromatin-associated proteins. Using a combination of genetics, biochemistry and single-molecule biophysics, we characterize how IDRs regulate the functions of the yeast MutLα (Mlh1–Pms...

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Detalles Bibliográficos
Autores principales: Kim, Yoori, Furman, Christopher M, Manhart, Carol M, Alani, Eric, Finkelstein, Ilya J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393296/
https://www.ncbi.nlm.nih.gov/pubmed/30541127
http://dx.doi.org/10.1093/nar/gky1244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393296/
https://www.ncbi.nlm.nih.gov/pubmed/30541127
http://dx.doi.org/10.1093/nar/gky1244

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