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Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
Intrinsically disordered regions (IDRs) are present in at least 30% of the eukaryotic proteome and are enriched in chromatin-associated proteins. Using a combination of genetics, biochemistry and single-molecule biophysics, we characterize how IDRs regulate the functions of the yeast MutLα (Mlh1–Pms...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393296/ https://www.ncbi.nlm.nih.gov/pubmed/30541127 http://dx.doi.org/10.1093/nar/gky1244 |