Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1

Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for ATR activation has been proposed to occur via stalled RNA polymerase II (RNAPII). However, how RNAPII might signal to activate ATR remains unknown. H...

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Detalles Bibliográficos
Autores principales: Landsverk, Helga B, Sandquist, Lise E, Sridhara, Sreerama C, Rødland, Gro Elise, Sabino, João C, de Almeida, Sérgio F, Grallert, Beata, Trinkle-Mulcahy, Laura, Syljuåsen, Randi G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393312/
https://www.ncbi.nlm.nih.gov/pubmed/30541148
http://dx.doi.org/10.1093/nar/gky1233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393312/
https://www.ncbi.nlm.nih.gov/pubmed/30541148
http://dx.doi.org/10.1093/nar/gky1233

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