Cargando…

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion

Introduction: Genetic polymorphisms in TCF7L2 are the strongest common risk variants for type 2 diabetes mellitus (T2D). We and others have shown that genetic variation in TCF7L2 and WFS1 affect incretin-stimulated insulin secretion. A recent genome-wide association study discovered genetic variants...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaghutriz, Benjamin Assad, Heni, Martin, Lutz, Stefan Zoltán, Fritsche, Louise, Machicao, Fausto, Staiger, Harald, Peter, Andreas, Häring, Hans-Ulrich, Fritsche, Andreas, Wagner, Róbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393347/ https://www.ncbi.nlm.nih.gov/pubmed/30846969 http://dx.doi.org/10.3389/fendo.2019.00072

Ejemplares similares

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
por: Heni, Martin, et al.
Publicado: (2010)

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
por: Müssig, Karsten, et al.
Publicado: (2009)

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity
por: Böhm, Anja, et al.
Publicado: (2017)

Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion
por: Heni, Martin, et al.
Publicado: (2012)

Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies
por: Wagner, Róbert, et al.
Publicado: (2017)

Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals
por: Linder, Katarzyna, et al.
Publicado: (2012)

Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
por: Heni, Martin, et al.
Publicado: (2010)

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content
por: Machicao, Fausto, et al.
Publicado: (2016)

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes
por: Heni, Martin, et al.
Publicado: (2011)

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations
por: Ordelheide, Anna-Maria, et al.
Publicado: (2017)

Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
por: Wagner, Robert, et al.
Publicado: (2011)

Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function
por: Herzberg-Schäfer, Silke A., et al.
Publicado: (2010)

Common Genetic Variation in the Human CTF1 Locus, Encoding Cardiotrophin-1, Determines Insulin Sensitivity
por: Lutz, Stefan Z., et al.
Publicado: (2014)

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
por: Böhm, Anja, et al.
Publicado: (2012)

Dietary Fiber Intake Modulates the Association Between Variants in TCF7L2 and Weight Loss During a Lifestyle Intervention
por: Heni, Martin, et al.
Publicado: (2012)

Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals
por: Wagner, Róbert, et al.
Publicado: (2020)

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans
por: Wagner, Robert, et al.
Publicado: (2014)

Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
por: Wagner, Robert, et al.
Publicado: (2022)

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
por: Haupt, Axel, et al.
Publicado: (2010)

Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
por: Hennige, Anita M., et al.
Publicado: (2008)

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
por: Müssig, Karsten, et al.
Publicado: (2010)

Sex-Specific Associations of Testosterone With Metabolic Traits
por: Lutz, Stefan Z., et al.
Publicado: (2019)

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans
por: Ordelheide, Anna-Maria, et al.
Publicado: (2016)

Low-Density Lipoprotein Cholesterol Is Associated With Insulin Secretion
por: Dannecker, Corinna, et al.
Publicado: (2021)

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention
por: Sailer, Corinna, et al.
Publicado: (2016)

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans
por: Lutz, Stefan Z., et al.
Publicado: (2018)

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
por: Kantartzis, Konstantinos, et al.
Publicado: (2009)

Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
por: Hudak, Sarah, et al.
Publicado: (2021)

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test
por: Babbar, Rohit, et al.
Publicado: (2018)

Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight
por: Wagner, Lore, et al.
Publicado: (2022)

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
por: Peter, Andreas, et al.
Publicado: (2010)

An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans
por: Tschritter, Otto, et al.
Publicado: (2011)

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans
por: Wagner, Robert, et al.
Publicado: (2013)

Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans
por: Sartorius, Tina, et al.
Publicado: (2012)

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers
por: Kächele, Martin, et al.
Publicado: (2015)

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
por: Staiger, Harald, et al.
Publicado: (2009)

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes
por: Staiger, Harald, et al.
Publicado: (2008)

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2008)

Polymorphisms within Novel Risk Loci for Type 2 Diabetes Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2007)

Diabetes and the Prostate: Elevated Fasting Glucose, Insulin Resistance and Higher Levels of Adrenal Steroids in Prostate Cancer
por: Lutz, Stefan Zoltán, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fpqkulh37vnctdc32nrjdb9jtj