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Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion

Introduction: Genetic polymorphisms in TCF7L2 are the strongest common risk variants for type 2 diabetes mellitus (T2D). We and others have shown that genetic variation in TCF7L2 and WFS1 affect incretin-stimulated insulin secretion. A recent genome-wide association study discovered genetic variants...

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Detalles Bibliográficos
Autores principales:	Jaghutriz, Benjamin Assad, Heni, Martin, Lutz, Stefan Zoltán, Fritsche, Louise, Machicao, Fausto, Staiger, Harald, Peter, Andreas, Häring, Hans-Ulrich, Fritsche, Andreas, Wagner, Róbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393347/ https://www.ncbi.nlm.nih.gov/pubmed/30846969 http://dx.doi.org/10.3389/fendo.2019.00072

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