Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis

Genetic diversity is a result of evolution, enabling multiple ways for one particular physiological activity. Here, we introduce this strategy into bioengineering. We design two hydroxytyrosol biosynthetic pathways using tyrosine as substrate. We show that the synthetic capacity is significantly imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Wei, Yao, Jun, Meng, Jie, Han, Wenjing, Tao, Yong, Chen, Yihua, Guo, Yixin, Shi, Guizhi, He, Yang, Jin, Jian-Ming, Tang, Shuang-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393456/
https://www.ncbi.nlm.nih.gov/pubmed/30814511
http://dx.doi.org/10.1038/s41467-019-08781-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393456/
https://www.ncbi.nlm.nih.gov/pubmed/30814511
http://dx.doi.org/10.1038/s41467-019-08781-2

Ejemplares similares