Cargando…

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma

The use of O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verhoeven, Jeroen, Hulpia, Fabian, Kersemans, Ken, Bolcaen, Julie, De Lombaerde, Stef, Goeman, Jan, Descamps, Benedicte, Hallaert, Giorgio, Van den Broecke, Caroline, Deblaere, Karel, Vanhove, Christian, Van der Eycken, Johan, Van Calenbergh, Serge, Goethals, Ingeborg, De Vos, Filip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393465/ https://www.ncbi.nlm.nih.gov/pubmed/30814660 http://dx.doi.org/10.1038/s41598-019-40013-x

Ejemplares similares

Assessment of the effect of therapy in a rat model of glioblastoma using [(18)F]FDG and [(18)F]FCho PET compared to contrast-enhanced MRI
por: Bolcaen, Julie, et al.
Publicado: (2021)

The Path Toward PET-Guided Radiation Therapy for Glioblastoma in Laboratory Animals: A Mini Review
por: Donche, Sam, et al.
Publicado: (2019)

Technical feasibility of [(18)F]FET and [(18)F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model
por: Verhoeven, Jeroen, et al.
Publicado: (2019)

Correction: Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats
por: Bolcaen, Julie, et al.
Publicado: (2016)

Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats
por: Bolcaen, Julie, et al.
Publicado: (2016)

Cost-Effectiveness of [(18)F] Fluoroethyl-L-Tyrosine for Temozolomide Therapy Assessment in Patients With Glioblastoma
por: Baguet, Tristan, et al.
Publicado: (2019)

Evaluating Hepatobiliary Transport with (18)F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance
por: De Lombaerde, Stef, et al.
Publicado: (2018)

Synthesis, in vitro and in vivo evaluation of 3β-[(18)F]fluorocholic acid for the detection of drug-induced cholestasis in mice
por: De Lombaerde, Stef, et al.
Publicado: (2017)

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study
por: De Meulenaere, Valerie, et al.
Publicado: (2019)

Chelator-Accelerated One-Pot ‘Click’ Labeling of Small Molecule Tracers with 2-[(18)F]Fluoroethyl Azide
por: Galante, Eva, et al.
Publicado: (2013)

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line
por: De Meulenaere, Valerie, et al.
Publicado: (2018)

Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[(18)F]fluoroethyl)-L-tyrosine ([(18)F]FET)
por: Lisova, Ksenia, et al.
Publicado: (2019)

A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma
por: Bolcaen, Julie, et al.
Publicado: (2021)

Hypoxia imaging with (18)F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts
por: Melsens, Elodie, et al.
Publicado: (2018)

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
por: Bahrami, Katayun, et al.
Publicado: (2022)

Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy
por: Everix, Liesbeth, et al.
Publicado: (2023)

In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain a clinically relevant rat model for triple negative breast cancer brain metastasis
por: De Meulenaere, Valerie, et al.
Publicado: (2020)

Intra-individual dynamic comparison of (18)F-PSMA-11 and (68)Ga-PSMA-11 in LNCaP xenograft bearing mice
por: Piron, Sarah, et al.
Publicado: (2020)

Development of a Rat Model for Glioma-Related Epilepsy
por: Bouckaert, Charlotte, et al.
Publicado: (2020)

Preclinical comparative study of [(18)F]AlF-PSMA-11 and [(18)F]PSMA-1007 in varying PSMA expressing tumors
por: Piron, Sarah, et al.
Publicado: (2022)

Exploring the purine core of 3′-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics
por: Hulpia, Fabian, et al.
Publicado: (2016)

First-in-human study of a novel cell death tracer [(99m)Tc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers
por: Metelerkamp Cappenberg, Taco, et al.
Publicado: (2023)

Impact of the molar activity and PSMA expression level on [(18)F]AlF-PSMA-11 uptake in prostate cancer
por: Piron, Sarah, et al.
Publicado: (2021)

A Fully Automated Radiosynthesis of [(18)F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[(18)F]Fluoroethyl Tosylate
por: Schoultz, Bent W., et al.
Publicado: (2013)

Radiosynthesis and pharmacokinetics of [(18)F]fluoroethyl bufalin in hepatocellular carcinoma-bearing mice
por: Yang, Zhaoshuo, et al.
Publicado: (2017)

Quantification of O-(2-[(18)F]fluoroethyl)-L-tyrosine kinetics in glioma
por: Koopman, Thomas, et al.
Publicado: (2018)

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents
por: Lin, Cai, et al.
Publicado: (2021)

The rs113883650 variant of SLC7A5 (LAT1) gene may alter brain phenylalanine content in PKU
por: Bik-Multanowski, Miroslaw, et al.
Publicado: (2021)

Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
por: Hulpia, Fabian, et al.
Publicado: (2018)

LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle †
por: Mazzulla, Michael, et al.
Publicado: (2021)

Perspective on the Use of DNA Repair Inhibitors as a Tool for Imaging and Radionuclide Therapy of Glioblastoma
por: Everix, Liesbeth, et al.
Publicado: (2022)

In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [(11)C]DASB in the Canine Brain
por: Van Laeken, Nick, et al.
Publicado: (2016)

The Effect of Various Doses of Phenylalanine Supplementation on Blood Phenylalanine and Tyrosine Concentrations in Tyrosinemia Type 1 Patients
por: van Ginkel, Willem G., et al.
Publicado: (2019)

PET quantification of [(18)F]MPPF in the canine brain using blood input and reference tissue modelling
por: Pauwelyn, Glenn, et al.
Publicado: (2019)

Preclinical PET imaging of HIP/PAP using 1'-(18)F-fluoroethyl-β-D-lactose
por: Yao, Shaobo, et al.
Publicado: (2017)

Investigation of Cerebral O-(2-[(18)F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models
por: Stegmayr, Carina, et al.
Publicado: (2020)

Quantitative parametric maps of O-(2-[(18)F]fluoroethyl)-L-tyrosine kinetics in diffuse glioma
por: Koopman, Thomas, et al.
Publicado: (2019)

Discrepant MR and [(18)F]Fluoroethyl-L-Tyrosine PET Imaging Findings in a Patient with Bevacizumab Failure
por: Galldiks, Norbert, et al.
Publicado: (2012)

Role of fluoroethyl tyrosine positron emission tomography-computed tomography scan in differentiating ewing's sarcoma from osteomyelitis
por: Aggarwal, Hitesh, et al.
Publicado: (2019)

O-(2-[(18)F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres
por: Filss, Christian P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pv8c49rrrlpep27qcvg8hn7seb