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Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome

The catalytic activity of the ribosome is mediated by RNA, yet proteins are essential for the function of the peptidyl transferase center (PTC). In eukaryotes, final assembly of the PTC occurs in the cytoplasm by insertion of the ribosomal protein Rpl10 (uL16). We determine structures of six interme...

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Detalles Bibliográficos
Autores principales: Zhou, Yi, Musalgaonkar, Sharmishtha, Johnson, Arlen W., Taylor, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393466/
https://www.ncbi.nlm.nih.gov/pubmed/30814529
http://dx.doi.org/10.1038/s41467-019-08880-0