Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes

Faithful meiotic chromosome inheritance and fertility rely on the stimulation of meiotic crossover recombination by potentially genotoxic DNA double-strand breaks (DSBs). To avoid excessive damage, feedback mechanisms down-regulate DSBs, likely in response to initiation of crossover repair. In Sacch...

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Detalles Bibliográficos
Autores principales: Subramanian, Vijayalakshmi V., Zhu, Xuan, Markowitz, Tovah E., Vale-Silva, Luis A., San-Segundo, Pedro A., Hollingsworth, Nancy M., Keeney, Scott, Hochwagen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393486/
https://www.ncbi.nlm.nih.gov/pubmed/30814509
http://dx.doi.org/10.1038/s41467-019-08875-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393486/
https://www.ncbi.nlm.nih.gov/pubmed/30814509
http://dx.doi.org/10.1038/s41467-019-08875-x

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