Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity

Growing evidence implicates α-synuclein aggregation as a key driver of neurodegeneration in Parkinson’s disease (PD) and other neurodegenerative disorders. Herein, the molecular and structural mechanisms of inhibiting α-synuclein aggregation by novel analogs of nordihydroguaiaretic acid (NDGA), a ph...

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Detalles Bibliográficos
Autores principales: Daniels, Malcolm J., Nourse, J. Brucker, Kim, Hanna, Sainati, Valerio, Schiavina, Marco, Murrali, Maria Grazia, Pan, Buyan, Ferrie, John J., Haney, Conor M., Moons, Rani, Gould, Neal S., Natalello, Antonino, Grandori, Rita, Sobott, Frank, Petersson, E. James, Rhoades, Elizabeth, Pierattelli, Roberta, Felli, Isabella, Uversky, Vladimir N., Caldwell, Kim A., Caldwell, Guy A., Krol, Edward S., Ischiropoulos, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393491/
https://www.ncbi.nlm.nih.gov/pubmed/30814575
http://dx.doi.org/10.1038/s41598-019-39480-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393491/
https://www.ncbi.nlm.nih.gov/pubmed/30814575
http://dx.doi.org/10.1038/s41598-019-39480-z

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