AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration

Phosphatase and tensin homolog (PTEN) acts as a brake for the phosphatidylinositol 3-kinase–AKT–mTOR complex 1 (mTORC1) pathway, the deletion of which promotes potent central nervous system (CNS) axon regeneration. Previously, we demonstrated that AKT activation is sufficient to promote CNS axon reg...

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Detalles Bibliográficos
Autores principales: Huang, Haoliang, Miao, Linqing, Yang, Liu, Liang, Feisi, Wang, Qizhao, Zhuang, Pei, Sun, Yang, Hu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393504/
https://www.ncbi.nlm.nih.gov/pubmed/30814515
http://dx.doi.org/10.1038/s41419-018-1289-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393504/
https://www.ncbi.nlm.nih.gov/pubmed/30814515
http://dx.doi.org/10.1038/s41419-018-1289-z

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