Cargando…
AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration
Phosphatase and tensin homolog (PTEN) acts as a brake for the phosphatidylinositol 3-kinase–AKT–mTOR complex 1 (mTORC1) pathway, the deletion of which promotes potent central nervous system (CNS) axon regeneration. Previously, we demonstrated that AKT activation is sufficient to promote CNS axon reg...
Autores principales: | Huang, Haoliang, Miao, Linqing, Yang, Liu, Liang, Feisi, Wang, Qizhao, Zhuang, Pei, Sun, Yang, Hu, Yang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393504/ https://www.ncbi.nlm.nih.gov/pubmed/30814515 http://dx.doi.org/10.1038/s41419-018-1289-z |
Ejemplares similares
-
mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016) -
The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration
por: Yang, Liu, et al.
Publicado: (2014) -
Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration
por: Zhang, Jie, et al.
Publicado: (2018) -
Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss
por: Huang, Haoliang, et al.
Publicado: (2017) -
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
por: Sun, Fang, et al.
Publicado: (2011)