Cargando…

Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology

The crucial role of VEGF receptor 2 (VEGFR2) signaling in the angiogenesis and metastasis of solid tumors has prompted the development of inhibitors with minimal bystander effects. Recently, Adnectin C has attracted attention for cancer treatment. To overcome the problematic properties of Adnectin,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aghaabdollahian, Safieh, Ahangari Cohan, Reza, Norouzian, Dariush, Davami, Fatemeh, Asadi Karam, Mohammad Reza, Torkashvand, Fatemeh, Vaseghi, Golnaz, Moazzami, Reza, Latif Dizaji, Sakineh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393559/ https://www.ncbi.nlm.nih.gov/pubmed/30814652 http://dx.doi.org/10.1038/s41598-019-39776-0

Ejemplares similares

Improvement of Certolizumab Fab′ properties by PASylation technology
por: Mazaheri, Somayeh, et al.
Publicado: (2020)

Comparison of E. coli based self-inducible expression systems containing different human heat shock proteins
por: Shariati, Fatemeh Sadat, et al.
Publicado: (2021)

Rapid screening of high expressing Escherichia coli colonies using a novel dicistronic-autoinducible system
por: Shariati, Fatemeh Sadat, et al.
Publicado: (2021)

MALDI-MS: a Rapid and Reliable Method for Drug-to-Antibody Ratio Determination of Antibody-Drug Conjugates
por: Abedi, Mehri, et al.
Publicado: (2019)

Synergistic Anti-Staphylococcal Activity Of Niosomal Recombinant Lysostaphin-LL-37
por: Sadeghi, Somayeh, et al.
Publicado: (2019)

Affinity Based Nano-Magnetic Particles for Purification of Recombinant Proteins in Form of Inclusion Body
por: Seyedinkhorasani, Masoud, et al.
Publicado: (2020)

Hyaluronic acid production and characterization by novel Bacillus subtilis harboring truncated Hyaluronan Synthase
por: Amjad Zanjani, Fatemeh Sadat, et al.
Publicado: (2022)

Adnectins: engineered target-binding protein therapeutics
por: Lipovšek, D.
Publicado: (2011)

Increment in protease activity of Lysobacter enzymogenes strain by ultra violet radiation
por: Kalahroudi, Reyhaneh Jafari, et al.
Publicado: (2020)

Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system
por: Shariati, Fatemeh Sadat, et al.
Publicado: (2022)

In silico analysis and in vivo assessment of a novel epitope-based vaccine candidate against uropathogenic Escherichia coli
por: Hasanzadeh, Sara, et al.
Publicado: (2020)

Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin
por: Cohan, Reza Ahangari, et al.
Publicado: (2011)

Woodchuck Hepatitis Virus Post-Transcriptional Regulation Element (WPRE) Promotes Anti-CD19 BiTE Expression in Expi293 Cells
por: Moazzami, Reza, et al.
Publicado: (2021)

An in-silico approach to develop of a multi-epitope vaccine candidate against SARS-CoV-2 envelope (E) protein
por: Ghafouri, Fatemeh, et al.
Publicado: (2020)

Synthesis and characterization of Gd(3+)-loaded hyaluronic acid-polydopamine nanoparticles as a dual contrast agent for CT and MRI scans
por: Shariati, Alireza, et al.
Publicado: (2023)

PASylated Urate Oxidase Enzyme: Enhancing Biocatalytic Activity, Physicochemical Properties, and Plasma Half-Life
por: Najjari, Abbas, et al.
Publicado: (2022)

The effect of manipulating glucuronic acid biosynthetic pathway in Bacillus subtilis strain on hyaluronic acid production
por: Afrasiabi, Shadi, et al.
Publicado: (2023)

Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors
por: Lipovšek, Daša, et al.
Publicado: (2018)

Designing and Development of a Tandem Bivalent Nanobody against VEGF(165)
por: Khodabakhsh, Farnaz, et al.
Publicado: (2021)

Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody
por: Torkashvand, Fatemeh, et al.
Publicado: (2015)

Development of a Multiepitope Vaccine Against SARS-CoV-2: Immunoinformatics Study
por: Ghafouri, Fatemeh, et al.
Publicado: (2022)

Utilization of Site-Specific Recombination in Biopharmaceutical Production
por: Ahmadi, Maryam, et al.
Publicado: (2016)

The effect of extremely low-frequency magnetic field (50–60 Hz) exposure on spontaneous apoptosis: The results of a meta-analysis
por: Mansourian, Mahsa, et al.
Publicado: (2016)

M918: A Novel Cell Penetrating Peptide for Effective Delivery of HIV-1 Nef and Hsp20-Nef Proteins into Eukaryotic Cell Lines
por: Rostami, Bahareh, et al.
Publicado: (2018)

Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer
por: Ganji, Mahmoud, et al.
Publicado: (2023)

A novel nanocomposite containing zinc ferrite nanoparticles embedded in carboxymethylcellulose hydrogel plus carbon nitride nanosheets with multifunctional bioactivity
por: Ganjali, Fatemeh, et al.
Publicado: (2023)

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
por: Schlapschy, Martin, et al.
Publicado: (2013)

PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology
por: Binder, Uli, et al.
Publicado: (2020)

Challenges to Improve the Stability and Efficacy of an Intravesical BCG Product
por: Hozouri, Hamidreza, et al.
Publicado: (2014)

In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A
por: Afshari, Elnaz, et al.
Publicado: (2023)

Characterization of a novel mCH3 conjugated anti-PcrV scFv molecule
por: Komijani, Samira, et al.
Publicado: (2021)

Synergistic Antibacterial Activity of Plant Peptide MBP-1 and Silver Nanoparticles Combination on Healing of Infected Wound Due to Staphylococcus aureus
por: Salouti, Mojtaba, et al.
Publicado: (2016)

Design and expression of fusion protein consists of HBsAg and Polyepitope of HCV as an HCV potential vaccine
por: Gholizadeh, Monireh, et al.
Publicado: (2015)

Anti-angiogenic peptides application in cancer therapy; a review
por: Shoari, Alireza, et al.
Publicado: (2021)

Development and Characterization of Nanoliposomal Hydroxyurea Against BT-474 Breast Cancer Cells
por: Akbari, Azam, et al.
Publicado: (2020)

Dynamics of host immune responses to SARS-CoV-2
por: Taherkhani, Reza, et al.
Publicado: (2021)

Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells
por: Ebadat, Saeedeh, et al.
Publicado: (2017)

Development of a bivalent protein-based vaccine candidate against invasive pneumococcal diseases based on novel pneumococcal surface protein A in combination with pneumococcal histidine triad protein D
por: Afshari, Elnaz, et al.
Publicado: (2023)

High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
por: Mendler, Claudia T, et al.
Publicado: (2014)

Direct Affinity Purification of Long‐Acting PASylated Proteins with Therapeutic Potential Using L‐Prolinamide for Mild Elution
por: Schilz, Jonas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_830roig6nm3aksnjnpopea5ibu