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Hydration shell differentiates folded and disordered states of a Trp-cage miniprotein, allowing characterization of structural heterogeneity by wide-line NMR measurements
Hydration properties of folded and unfolded/disordered miniproteins were monitored in frozen solutions by wide-line (1)H-NMR. The amount of mobile water as function of T (−80 °C < T < 0 °C) was found characteristically different for folded (TC5b), semi-folded (pH < 3, TCb5(H+)) and disorder...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393587/ https://www.ncbi.nlm.nih.gov/pubmed/30814556 http://dx.doi.org/10.1038/s41598-019-39121-5 |