Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer

OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP inhibitor, has an anti-tumor effect on high grade serous ovarian cancer, but its effects on cellular s...

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Detalles Bibliográficos
Autores principales: Wang, Zehua, Gao, Jianwen, Zhou, Jiabing, Liu, Haiou, Xu, Congjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393639/
https://www.ncbi.nlm.nih.gov/pubmed/30740957
http://dx.doi.org/10.3802/jgo.2019.30.e26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393639/
https://www.ncbi.nlm.nih.gov/pubmed/30740957
http://dx.doi.org/10.3802/jgo.2019.30.e26

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