Design, synthesis, and pharmacology of some oxadiazole and hydroxypyrazoline hybrids bearing thiazoyl scaffold: antiproliferative activity, molecular docking and DNA binding studies

A series of oxadiazole (7a-l) and hydroxypyrazoline derivatives (8a-l) incorporating thiazole were synthesized and characterized by spectral analysis ((1)H-NMR, (13)C-NMR, Mass, and FT-IR). The synthesized compounds were screened for their in vitro cytotoxicity against MDA-MB231 and HT-29 human cell...

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Detalles Bibliográficos
Autores principales: Santosh, Rangappa, Prabhu, Ashwini, Selvam, Mukunthan K., Krishna, Panchangam M., Nagaraja, Gundibasappa K., Rekha, Punchappady D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393698/
https://www.ncbi.nlm.nih.gov/pubmed/30886919
http://dx.doi.org/10.1016/j.heliyon.2019.e01255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393698/
https://www.ncbi.nlm.nih.gov/pubmed/30886919
http://dx.doi.org/10.1016/j.heliyon.2019.e01255

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