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Design, synthesis, and pharmacology of some oxadiazole and hydroxypyrazoline hybrids bearing thiazoyl scaffold: antiproliferative activity, molecular docking and DNA binding studies
A series of oxadiazole (7a-l) and hydroxypyrazoline derivatives (8a-l) incorporating thiazole were synthesized and characterized by spectral analysis ((1)H-NMR, (13)C-NMR, Mass, and FT-IR). The synthesized compounds were screened for their in vitro cytotoxicity against MDA-MB231 and HT-29 human cell...
Autores principales: | Santosh, Rangappa, Prabhu, Ashwini, Selvam, Mukunthan K., Krishna, Panchangam M., Nagaraja, Gundibasappa K., Rekha, Punchappady D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393698/ https://www.ncbi.nlm.nih.gov/pubmed/30886919 http://dx.doi.org/10.1016/j.heliyon.2019.e01255 |
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