Evaluation of the effects of formulation, food, or a proton-pump inhibitor on the pharmacokinetics of glasdegib (PF-04449913) in healthy volunteers: a randomized phase I study

PURPOSE: To demonstrate the bioequivalence of the planned maleate salt-based commercial glasdegib tablet formulation [International Council for Harmonization (ICH) glasdegib] to the clinical di-hydrochloride (di-HCl) salt-based glasdegib formulation (di-HCl glasdegib). Additionally, to estimate the...

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Detalles Bibliográficos
Autores principales: Shaik, Naveed, Hee, Brian, Wei, Hua, LaBadie, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394474/
https://www.ncbi.nlm.nih.gov/pubmed/30536154
http://dx.doi.org/10.1007/s00280-018-3748-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394474/
https://www.ncbi.nlm.nih.gov/pubmed/30536154
http://dx.doi.org/10.1007/s00280-018-3748-8

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