Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin(®)), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors

PURPOSE: The aim of the study was to characterize the population pharmacokinetics (PK) of the intravenous formulation of trastuzumab, assess the impact of patient and pathological covariates on trastuzumab PK, and perform simulations to support dosing recommendations in special situations. METHODS:...

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Detalles Bibliográficos
Autores principales: Quartino, Angelica L., Li, Hanbin, Kirschbrown, Whitney P., Mangat, Ranvir, Wada, D. Russell, Garg, Amit, Jin, Jin Y., Lum, Bert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394489/
https://www.ncbi.nlm.nih.gov/pubmed/30467591
http://dx.doi.org/10.1007/s00280-018-3728-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394489/
https://www.ncbi.nlm.nih.gov/pubmed/30467591
http://dx.doi.org/10.1007/s00280-018-3728-z

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