Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade

Myeloid-derived suppressor cells (MDSCs) are immature monocytes and granulocytes that impede immune-mediated clearance of malignant cells by multiple mechanisms, including the formation of immunosuppressive reactive oxygen species (ROS) via the myeloid cell NADPH oxidase (NOX2). Histamine dihydrochl...

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Detalles Bibliográficos
Autores principales: Grauers Wiktorin, Hanna, Nilsson, Malin S., Kiffin, Roberta, Sander, Frida Ewald, Lenox, Brianna, Rydström, Anna, Hellstrand, Kristoffer, Martner, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394491/
https://www.ncbi.nlm.nih.gov/pubmed/30315349
http://dx.doi.org/10.1007/s00262-018-2253-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394491/
https://www.ncbi.nlm.nih.gov/pubmed/30315349
http://dx.doi.org/10.1007/s00262-018-2253-6

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