IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans

NADPH is a reducing equivalent that maintains redox homeostasis and supports reductive biosynthesis. Lack of major NADPH-producing enzymes predisposes cells to growth retardation and demise. It was hypothesized that double deficiency of the NADPH-generating enzymes, GSPD-1 (Glucose-6-phosphate 1-deh...

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Detalles Bibliográficos
Autores principales: Yang, Hung-Chi, Yu, Hsiang, Liu, You-Cheng, Chen, Tzu-Ling, Stern, Arnold, Lo, Szecheng J., Chiu, Daniel Tsun-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394583/
https://www.ncbi.nlm.nih.gov/pubmed/30661088
http://dx.doi.org/10.1007/s00109-018-01740-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394583/
https://www.ncbi.nlm.nih.gov/pubmed/30661088
http://dx.doi.org/10.1007/s00109-018-01740-2

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