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Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset, progressive neurodegenerative disorder with no known cure. Cu/Zn-superoxide dismutase (SOD1) was the first identified protein associated with familial ALS (fALS). Recently, TAR DNA-binding protein 43 (TDP-43) has been found to be a princip...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394608/ https://www.ncbi.nlm.nih.gov/pubmed/29982983 http://dx.doi.org/10.1007/s12035-018-1218-2 |